Mitochondrial function is a contributing, but not necessarily essential factor to lower the levels of triglycerides in plasma, according to Carine Lindquist‘s PhD thesis.


MAIN RESULTS:

  1. 1-triple TTA reduces triglyceride levels in plasma as a result of increased hepatic mitochondrial oxidation.
  2. 1-triple TTA reduces triglyceride levels in plasma even when levels of L-carnitine are low.
  3. 1-triple TTA probably influences triglyceride clearance and biosynthesis.

THESIS DEFENCE:

Thesis: Mitochondrial function in the regulation of plasma and liver triacylglycerols
Candidate: Carine Lindquist
Time: April 27, 2018 at 11:15
Place: Univeristy of Bergen: BB-building, Auditorium 1
Link to university website (in Norwegian)


SUMMARY:

(1) Rats fed for three weeks with 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA) had a five-fold increase of hepatic mitochondrial oxidation of fatty acids. Triglyceride levels in both plasma and liver decreased substantially, probably as a consequence of downregulated APOC-III and upregulated LPL and the VLDL receptor.

(2) L-carnitine is important for the catabolism of long-chain fatty acids in the mitochondria, but Lindquists second study shows that 1-triple TTA increases mitochondrial fatty acid oxidation even when L-carnitine levels are low. The results indicate that 1-triple TTA also influences changes in plasma clearance and reduced biosynthesis of triglycerides.


REFERENCES:

(1) Lindquist, C., Bjørndal, B., Rossmann, C. R., Tusubira, D., Svardal, A., Røsland, G. V., Tronstad, K. J., Hallström,, S., & Berge, R. K. (2017). Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in ratsJournal of lipid research58(7), 1362-1373.

(2) Lindquist, C., Bjørndal, B., Rossmann, C. R., Svardal, A., Hallström, S., & Berge, R. K. (2018). A fatty acid analogue targeting mitochondria exerts a plasma triacylglycerol lowering effect in rats with impaired carnitine biosynthesisPloS one13(3), e0194978.

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