Systolic as well as diastolic cardiac dysfunction is prevalent in patients with the connective tissue disease systemic sclerosis, shows the PhD thesis of Anders Heiervang Tennøe.


MAIN RESULTS:

  1. Left ventricular diastolic dysfunction is a prevalent and strong predictor of death in systemic sclerosis.
  2. In systemic sclerosis, right ventricular systolic function deteriorates with time and predicts mortality.
  3. Biomarkers in blood associate with cardiac function and predicts death in patients with systemic sclerosis.

THESIS DEFENCE:

Thesis: Cardiac Risk Profiling in Systemic Sclerosis
Candidate: Anders Heiervang Tennøe
Time: May 29, 2020 at 11:15
Place: Online-based solution, due to the covid-19 situation
Link to university website


SUMMARY:

The studies in the thesis include up to 333 patients with systemic sclerosis treated at Oslo University Hospital between 2003 and 2016. More than half of them were assessed with cardiac ultrasound twice.

(1) 17% of patients were diagnosed with left ventricular diastolic dysfunction at baseline. The proportion increased to 29% after a median follow-up period of 3.4 years. 57% of patients with baseline diastolic dysfunction died during follow-up, compared to only 13% of the patients with normal function.

Diastolic dysfunction was a stronger predictor of death than pulmonary hypertension. Half of the 86 patients who had performed right heart catheterization had pulmonary hypertension, of which 60% died during follow-up.

(2) 12% of the patients had an ejection fraction below 50%, and 24% had global longitudinal strain greater than −17.0%, indicating left ventricular systolic dysfunction. The proportions were stable during 3.3 years follow-up. 10% had right ventricular systolic dysfunction measured with TAPSE at baseline, increasing to 15% at follow-up. Only right ventricular systolic function independently predicted mortality.

(3) The levels of tumor necrosis factor related apoptosis (TRAIL) in blood associate with both left ventricular diastolic dysfunction and right ventricular systolic dysfunction in systemic sclerosis. Moreover, patients with right ventricular systolic dysfunction also have higher levels of osteopontin and antiopoietin-2. Changes in all these markers over time predict mortality.


REFERENCES:

(1) Tennøe, A. H., Murbraech, K., Andreassen, J. C., Fretheim, H., Garen, T., Gude, E., Andreassen, A., Aakhus, S., Molberg, Ø., & Hoffmann-Vold, A. M. (2018). Left ventricular diastolic dysfunction predicts mortality in patients with systemic sclerosis. Journal of the American College of Cardiology72(15), 1804-1813.

(2) Tennøe, A. H., Murbræch, K., Andreassen, J. C., Fretheim, H., Midtvedt, Ø., Garen, T., Dalen, H., Gude, E., Andreassen, A., Aakhus, S., Molberg, Ø., & Hoffmann-Vold, A. M. (2019). Systolic Dysfunction in Systemic Sclerosis: Prevalence and Prognostic Implications. ACR open rheumatology1(4), 258-266.

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