MAIN RESULTS:

1. Lymph vessels in the skin might not play a role in blood pressure regulation.

THESIS DEFENCE:

Thesis: Study of the role of skin lymphatics in electrolyte and blood pressure regulation
Candidate: Tore Reikvam
Time: February 21, 2020 at 12:15
Place: Haukeland University Hospital, Armauer Hansens Hus: Auditorium AHH
Link to university website (in Norwegian)

SUMMARY:

Lymph vessels in the skin do not seem to affect salt accumulation in the skin, nor blood pressure. Compared to normal mice, there were no difference in saline storage or blood pressure increase following increased salt intake in mice with deficient or reduced network of lymphatic vessels in the skin. Thus, the results from Reikvam’s thesis question an established truth within recent hypertension research.

REFERENCES:

(1) Karlsen, T. V., Reikvam, T., Tofteberg, A., Nikpey, E., Skogstrand, T., Wagner, M., Tenstad, O., & Wiig, H. (2017). Lymphangiogenesis facilitates initial lymph formation and enhances the dendritic cell mobilizing chemokine CCL21 without affecting migration. Arteriosclerosis, thrombosis, and vascular biology, 37(11), 2128-2135.

Karlsen, T. V., Nikpey, E., Han, J., Reikvam, T., Rakova, N., Castorena-Gonzalez, J. A., Davis, M. J., Titze, J. M., Tenstad, O., & Wiig, H. (2018). High-salt diet causes expansion of the lymphatic network and increased lymph flow in skin and muscle of rats. Arteriosclerosis, thrombosis, and vascular biology, 38(9), 2054-2064.