One carbon metabolism describes a series of metabolic reactions in our body, and Vegard Lysne has studied how dietary habits influence these metabolic processes.

MAIN RESULTS:

1. Long-term activation of the receptor PPARα increases several metabolites related to one-carbon metabolism and B-vitamin status in rats.
2. Short-term PPARα activation reduced fatty acids in cardiac tissue.
3. Dietary composition associates with one carbon metabolites in heart patients.

THESIS DEFENCE:

Thesis: Biomarkers of one-carbon metabolism and B-vitamin status
Candidate: Vegard Lysne
Time: October 4, 2019 at 11:15
Place: Haukeland University Hospital, Armauer Hansens Hus: Auditorium
Link to university website (in Norwegian)

SUMMARY:

(1) Rats fed a high-fat diet with components that activate the Peroxisome Proliferator-Activated Receptor (PPARα) had increased plasma levels of dimetylglycine. Dimetylglycine has previously been linked to increased risk of cardiovascular disease. PPARα activation also increased vitamin B3 levels, as well as methylnicotinamide, methylmalonic acid and pyridoxal.

(3) Protein intake and fatty acid composition appear to influence one carbon metabolism in patients with coronary artery disease. Lysne and co-workers have studied the association between self-reported diet and biomarkers of one carbon metabolism in more than 2000 heart patients.

REFERENCES:

(1) Lysne, V., Strand, E., Svingen, G., Bjørndal, B., Pedersen, E., Midttun, Ø., Olsen, T., Ueland, P. M., Berge, R. K., & Nygård, O. (2016). Peroxisome proliferator-activated receptor activation is associated with altered plasma one-carbon metabolites and B-vitamin status in rats. Nutrients, 8(1), 26.

(2) Strand, E., Lysne, V., Grinna, M. L., Bohov, P., Svardal, A., Nygård, O., Berge, R: K., & Bjørndal, B. (2019). Short-Term Activation of Peroxisome Proliferator-Activated Receptors and Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats. PPAR Research, 2019.