How does NEIL3 deficiency and RNA modifications affect atherosclerosis? Ana M. T. Quiles-Jiménez‘ PhD thesis gives some answers.
Thesis: Molecular mechanisms of atherosclerotic disease. Studies on the role of the DNA glycosylase NEIL3 and the epitranscriptome in the development of atherosclerosis
Candidate: Ana M. T. Quiles-Jiménez
Time: November 18, 2020 at 11:15
Place: Online-based solution, due to the covid-19 situation
Link to university website
(1) In atherosclerosis, levels of methyltransferases (‘writers’), binding proteins (‘readers’) and demethylases (‘erasers’) involved in methylations occurring in rRNA and mRNA are altered. The changes are accompanied by a marked downregulation of the well-known RNA modification N6-methyladenosine.
(2) NEIL3 affects vascular smooth muscle cells phenotypic identity, and could be a new player in atherosclerosis. Vascular smooth muscle cells accumulate DNA damage, which can promote plaque instability and lead to rupture and acute coronary heart disease. NEIL3 repairs damaged DNA.
(1) Quiles-Jiménez, A., Gregersen, I., de Sousa, M. M. L., Abbas, A., Kong, X. Y., Alseth, I., Alseth, I., Holm, S., Dahl, T. B:, Skagen, K., Skjelland, M., Aukrust, P., Bjørås, M., & Halvorsen, B. (2020). N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis. Biochemical and Biophysical Research Communications.
Priority at NORHEART events
Opportunities for travel and exchange grants
E-mail updates on key NORHEART events
23 students completed NORHEART’s Introductory Course to Cardiovascular Research and Medicine in Oslo 17–21 October. As usual,…
The 20th Annual Norwegian Symposium on Heart Research was arranged by NORHEART and the Department…
The Norwegian Health Association has awarded the prestigious 2022 Heart Research Award (Hjerteforskningsprisen) to professor Eva…
NORHEART was established in 2013 as part of the research school program of the Research…