Ingeborg Eskerud‘s PhD thesis gives new knowledge about possible causes of myocardial ischemia in persons with non-obstructive coronary artery disease.


MAIN RESULTS:

  1. Total plaque burden associates with myocardial perfusion independent of having large coronary stenoses.
  2. Left ventricular hypertrophy could contribute to stress-induced myocardial ischemia in non-obstructive heart patients with stable angina.
  3. Aortic stiffness is also linked to stress-induced myocardial ischemia and larger extent of ischemia in this patient group.

THESIS DEFENCE:

Thesis: Myocardial ischemia in non-obstructive coronary artery disease
Candidate: Ingeborg Eskerud
Time: September 22, 2020 at 12:15
Place: Online-based solution, due to the covid-19 situation
Link to university website (in Norwegian)


SUMMARY:

(1) Women with NSTEMI more often have non-obstructive coronary heart disease, but the total plaque burden is similar to men. The higher burden of coronary artery plaques, the higher is the risk of having severe myocardial hypoperfusion, and this association is independent of presence of significant coronary stenoses.

The researchers have assessed coronary artery plaque area and myocardial perfusion in 108 patients, of which 35 were women. Compared to 91% of the men, only 74% of the female patients had ≥50% coronary artery stenosis.

(2/3) Patients with stable angina and non-obstructive coronary artery disease are more likely to get stress-induced myocardial ischemia if they also have left ventricular hypertrophyHigher aortic stiffness is also independently linked to stress-induced myocardial ischemia. Moreover, both left ventricular hypertrophy and aortic stiffness associate with larger extent of ischemia in these patients..

The studies include 125 and 132 patients, of which approximately 50% had myocardial ischemia during stress echocardiography.


REFERENCES:

(1) Eskerud, I., Gerdts, E., Nordrehaug, J. E., & Lønnebakken, M. T. (2015). Global coronary artery plaque area is associated with myocardial hypoperfusion in women with non-ST elevation myocardial infarctionJournal of Women’s Health24(5), 367-373.

(2) Lønnebakken, M. T., Eskerud, I., Larsen, T. H., Midtbø, H. B., Kokorina, M. V., & Gerdts, E. (2019). Impact of aortic stiffness on myocardial ischaemia in non-obstructive coronary artery diseaseOpen Heart6(1), e000981.

(3) Eskerud, I., Gerdts, E., Larsen, T. H., & Lønnebakken, M. T. (2019). Left ventricular hypertrophy contributes to Myocardial Ischemia in Non-obstructive Coronary Artery Disease (the MicroCAD study)International Journal of Cardiology286, 1-6.

Latest News

May 28, 2024

Photos from the workshop on Advancing Ischemic Heart Disease Research

Approximately 25 researchers met in Trondheim for the new workshop called “Advancing Ischemic Heart Disease…

Read more
May 14, 2024

Photos from Course in Cardiac Mechanics 2024

Cardiac researchers and clinical cardiologists need to know key concepts and terms for measuring and describing…

Read more
April 28, 2024

Professor Kristina H. Haugaa receives the 2024 Heart Research Award

The Norwegian Health Association has awarded the prestigious 2024 Heart Research Award (Hjerteforskningsprisen) to professor Kristina…

Read more
September 08, 2023

Annual Symposium 2023: Winners and photos

More than 100 participants attended the 21st Annual Norwegian Symposium on Heart Research, hosted by…

Read more
Norheart uses cookies for analytical purposes, content and ads customisation, and to further develop our services.
Accept
Learn more
Show again