Vibeke Bratseth‘s PhD thesis looks at circulating microvesicles and prothrombotic activity in patients with diabetes.


MAIN RESULTS:

  1. Coronary artery disease patients with type 2-diabetes have higher levels of circulating microvesicles if they also have albuminuria.
  2. Children with type 1-diabetes do not have increased levels of circulating microvesicles.
  3. Prothrombotic markers are not elevated in children with type 1-diabetes.

THESIS DEFENCE:

Thesis: Pro-thrombotic activity and circulating microvesicles in diabetes, with and without CAD. Special emphasis on the influence of exercise training and longitudinal development
Candidate: Vibeke Bratseth
Time: December 3, 2020 at 12:15
Place: Online-based solution, due to the covid-19 situation
Link to university website


SUMMARY:

(1) Levels of circulating microvesicles are higher in coronary artery patients with type 2 diabetes and albuminuria than in patients without albuminuria. One year of exercise training does not seem to influence expression of circulation microvesicles in this patient group.

75 patients with combined type 2-diabetes and coronary artery disease were included in the study, of which 25 had albuminuria.

(2/3) Neither circulating microvesicles nor procoagulant activity are increased in children and adolescents with type 1-diabetes, compared to healthy children. Furthermore, levels are not correlated to cardiovascular risk factors.

Children with diabetes do however have elevated levels of tissue factor pathway inhibitor, probably reflecting increased endothelial activation. 314 children with diabetes and 120 controls were included in the study. The children were assessed two times with five years between assessments.


REFERENCES:

(1) Bratseth, V., Chiva-Blanch, G., Byrkjeland, R., Solheim, S., Arnesen, H., & Seljeflot, I. (2019). Elevated levels of circulating microvesicles in coronary artery disease patients with type 2 diabetes and albuminuria: effects of exercise training. Diabetes and Vascular Disease Research16(5), 431-439.

(2) Bratseth, V., Margeirsdottir, H. D., Heier, M., Solheim, S., Arnesen, H., Dahl‐Jørgensen, K., & Seljeflot, I. (2020). Procoagulant activity in children and adolescents on intensive insulin therapyPediatric Diabetes21(3), 496-504.

(3) Bratseth, V., Margeirsdottir, H. D., Chiva-Blanch, G., Heier, M., Solheim, S., Arnesen, H., Dahl-Jørgense, K. D., & Seljeflot, I. (2020). Annexin V+ Microvesicles in Children and Adolescents with Type 1 Diabetes: A Prospective Cohort StudyJournal of Diabetes Research2020.

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