Kuan Yang‘s research focuses on pattern recognition receptors influencing inflammation.
Thesis: Metabolic Regulation of TLR4 and NLRP3 Activities
Candidate: Kuan Yang
Time: November 25, 2020 at 12:15
Place: Online-based solution, due to the covid-19 situation
Link to university website
(1) Inhibition of NAD+ synthesis downregulates the synthesis of toll-like receptor 4-dependent cytokines in human primary monocytes. NAD+-inhibition also inhibits phosphorylation of several proteins involved in the toll-like receptor 4signal pathway.
(2) Serum starvation of cardiac fibroblasts reduces levels of pro-interleukin-1β protein induced by toll-like receptor 4. Tumor necrosis factor, interleukin-6 and inflammasomes proteins are not affected.
To the researchers surprise, pro-interleukin-1β protein levels were increased by mTOR inhibition and degraded by autophagy inhibition. The results suggest that mTOR regulates degradation of pro-interleukin-1β in cardiac fibroblasts through proteasomes but not autophagy.
(3) Interleukin-1β release is attenuated upon NLRP3 inflammasome activation in human monocytes and macrophages treated with CD38 inhibitors. These findings support that CD38 promote NLRP3 activity by increasing cytosolic Ca2+ levels.
(1) Yang, K., Lauritzen, K. H., Olsen, M. B., Dahl, T. B., Ranheim, T., Ahmed, M. S., & Sandanger, Ø. (2019). Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes. The Journal of Immunology, 203(6), 1598-1608.
Priority at NORHEART events
Opportunities for travel and exchange grants
E-mail updates on key NORHEART events
23 students completed NORHEART’s Introductory Course to Cardiovascular Research and Medicine in Oslo 17–21 October. As usual,…
The 20th Annual Norwegian Symposium on Heart Research was arranged by NORHEART and the Department…
The Norwegian Health Association has awarded the prestigious 2022 Heart Research Award (Hjerteforskningsprisen) to professor Eva…
NORHEART was established in 2013 as part of the research school program of the Research…