Anne Bethke has evaluated what myocardial perfusion recorded with angiography and cardiac MRI can tell us about long-term cardiac function after successful PCI treatment.


  1. Myocardial perfusion recorded on angiography associates with infarct size and left ventricular function four months after PCI.
  2. Perfusion imaging with cardiac MRI predicts reduced cardiac function following STEMI.
  3. Patients with low myocardial perfusion a few days after PCI still have reduced perfusion four months later.


Thesis: Microvascular perfusion in STEMI patients in infarcted and remote myocardium: Angiographic and CMR findings
Candidate: Anne Bethke
Time: March 22 at 13:15
Place: Oslo University Hospital, Ullevål, Kreftsenteret: Auditorium 1
Link to university website


(1) Reduced myocardial perfusion shown on angiography immediately after PCI predicts reduced left ventricular ejection fraction and increased infarct size in patients with ST-elevation myocardial infarction. Also CMR first-pass perfusion imaging performed a few days after PCI is associated with reduced left ventricular function at follow-up.

Bethke recorded myocardial perfusion with angiography and CMR in 198 STEMI patients. The cardiac outcomes were measured four months later by cardiac magnetic resonance imaging. CMR first-pass perfusion improved after four months, but was still reduced in the patients with the lowest initial perfusion.

(2) Myocardial perfusion recorded with CMR a few days after treatment for STEMI is lower in the infarcted area compared to the area of the ventricle that is not directly affected. The difference diminishes over time. Patients with low perfusion have lower ejection fraction, larger infarct size and area at risk, smaller myocardial salvage and higher occurence of microvascular obstrauction.


(1) Bethke, A., Shanmuganathan, L., Andersen, G. Ø., Eritsland, J., Swanson, D., Kløw, N. E., & Hoffmann, P. (2019). Microvascular perfusion in infarcted and remote myocardium after successful primary PCI: angiographic and CMR findingsEuropean radiology29(2), 941-950.

(2) Bethke, A., Shanmuganathan, L., Shetelig, C., Swanson, D., Andersen, G. Ø., Eritsland, J., Kløw, N. E., & Hoffmann, P. (2018). MR findings of microvascular perfusion in infarcted and remote myocardium early after successful primary PCI. PloS one13(11), e0206723.

Latest News

September 08, 2023

Annual Symposium 2023: Winners and photos

More than 100 participants attended the 21st Annual Norwegian Symposium on Heart Research, hosted by…

Read more
April 30, 2023

Professor Dan Atar receives the 2023 Heart Research Award

The Norwegian Health Association has awarded the prestigious 2023 Heart Research Award (Hjerteforskningsprisen) to professor Dan…

Read more
October 31, 2022

Pictures from Introductory Course to Cardiovascular Research and Medicine 2022

23 students completed NORHEART’s Introductory Course to Cardiovascular Research and Medicine in Oslo 17–21 October. As usual,…

Read more
October 04, 2022

Five abstract award winners at the Annual Symposium

The 20th Annual Norwegian Symposium on Heart Research was arranged by NORHEART and the Department…

Read more
Norheart uses cookies for analytical purposes, content and ads customisation, and to further develop our services.
Learn more
Show again