Polarizing blood cardioplegia with esmolol, adenosin and magnesium could reduce cardiac damage following open heart surgery, according to Terje Aass‘ research.
Thesis: Polarizing versus depolarizing blood cardioplegia. An experimental study of myocardial function, metabolism and ultrastructure following cardiopulmonary bypass and cardioplegic arrest
Candidate: Terje Aass
Time: January 11, 2019 at 11:15
Place: Haukeland University Hospital, Armauer Hansen House: Auditorium
Link to university website (in Norwegian)
Potassium-based depolarizing oxygenated blood cardioplegia is the standard method used to protect an arrested heart during open-chest surgery. In his research, Aass has tested an experimental method of polarizing oxygenated blood cardioplegia with the beta blocker esmolol, adenosin and magnesium in the cardioplegic solution.
(1) Myocardial function is equally well preserved after polarizing and depolarizing cardiac arrest. Arrested pig hearts treated with the polarizing solution had increased contractility three hours after the surgical procedure. Troponin T levels were equal in the two groups following surgery.
The study randomized 20 pigs to either polarizing or depolarizing cardioplegic arrest for one hour. Based on the results, the researchers recommend that the polarizing method is evaluated also in humans.
(2) Biopsies from the pigs’ hearts revealed higher levels of biochemical energy substrates during and shortly following polarized cardioplegic arrest compared to depolarized cardioplegic arrest. Creatine phosphate and ATP increased, whereas mitochondrial surface-to-volume ratio decreased. Three hours after surgery these differences were no longer present.
(3) In the final experiment, the cardiac arrest was prolonged to two hours. The polarized method improved left ventricular mechanical efficiency by improving the ratio between total pressure-volume area and blood flow rate compared to the depolarized method.
(1) Aass, T., Stangeland, L., Moen, C. A., Salminen, P. R., Dahle, G. O., Chambers, D. J., Markou, T., Eliassen, F., Urban, M., Haaverstad, R., Matre, K., og Grong, K. (2016). Myocardial function after polarizing versus depolarizing cardiac arrest with blood cardioplegia in a porcine model of cardiopulmonary bypass. European Journal of Cardio-Thoracic Surgery, 50(1), 130-139.
(2) Aass, T., Stangeland, L., Chambers, D. J., Hallström, S., Rossmann, C., Podesser, B. K., & Grong, K. (2017). Myocardial energy metabolism and ultrastructure with polarizing and depolarizing cardioplegia in a porcine model. European Journal of Cardio-Thoracic Surgery, 52(1), 180-188.
(3) Aass, T., Stangeland, L., Moen, C. A., Solholm, A., Dahle, G. O., Chambers, D. J., Urban, M., Nesheim, K., Haaverstad, R., Matre, K. & Grong, K. (2018). Left ventricular dysfunction after two hours of polarizing or depolarizing cardioplegic arrest in a porcine model. Perfusion, 34(1), 67-75.
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