MAIN RESULTS:

1. Circulating vitamin A can modify the association between apolipoprotein B and risk of myocardial infarction.

2. Circulating vitamin A can modify the association between homocysteine and risk of myocardial infarction.
3. Circulating vitamin A is positively associated with levels of creatinine, cysteine and uric acid.

THESIS DEFENCE:

Thesis: Lipids, Homocysteine and Vitamin A. Perspectives and new hypotheses from patients with cardiovascular disease
Candidate: Thomas Olsen
Time: January 16, 2020 at 13:15
Place: University of Oslo, Domus Odontologica: Store auditorium
Link to university website

SUMMARY:

(1/2) Higher concentrations of apolipoprotein B and homocysteine are linked to increased risk of myocardial infarction in patients with stable angina, but only if they also have high levels of vitamin A (retinol). Higher levels of vitamin A also modifies the association between low levels of apolipoprotein A1 and increased risk of myocardial infarction.

The studies include patients with stable angina pectoris, followed for a median of nearly five years. 8% of them had an acute myocardial infarction during follow-up. Olsen and colleagues conclude that circulating vitamin A can modify the association between apolipoproteins, homocysteine and subsequent myocardial infarction.

(3) Dietary intake does not seem to influence blood levels of vitamin A much in patients with stable angina. Olsen’s study shows a weak association between self-reported meat and vegetable intake and circulating retinol, and no association for other dietary variables.

On the other hand, creatinine – a marker of impaired renal function – is positively associated with serum levels of vitamin A. Moreover, higher levels of the amino acid cysteine and the inflammatory marker uric acid are also linked to higher vitamin A concentrations.

REFERENCES:

(1) Olsen, T., Vinknes, K. J., Svingen, G. F., Pedersen, E. R., Tell, G. S., Blomhoff, R., Drevon, C. A., Ueland, P. M., Midttun, Ø., Refsum, H., & Nygård, O. K. (2017). Cardiovascular disease risk associated with serum apolipoprotein B is modified by serum vitamin A. Atherosclerosis, 265, 325-330.

(2) Olsen, T., Vinknes, K. J., Svingen, G. F., Pedersen, E. R., Dhar, I., Tell, G. S., Blomhoff, R., Ueland, P. M., Midttun, Ø., Refsum, H., & Nygård, O. K. (2018). The risk association of plasma total homocysteine with acute myocardial infarction is modified by serum vitamin A. European journal of preventive cardiology, 25(15), 1612-1620.

(3) Olsen, T., Vinknes, K. J., Blomhoff, R., Lysne, V., Midttun, Ø., Dhar, I., Ueland, P. M., Svingen, G. F. T., Pedersen, E. K. R., Drevon, C. A., Refsum, H., & Nygård, O. K. (2019). Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease. European journal of nutrition, 1-11.