By use of Mendelian Randomization, Gunn-Helen Øiseth Moen has examined whether vitamin B12 is likely to causally affect the risk of cardiometabolic disease.
- Vitamin B12 does probably not have a causal effect on most cardiovascular risk factors or disease.
Thesis: Genetic and environmental etiology of glucose metabolism and cardiometabolic traits during pregnancy and in later life
Candidate: Gunn-Helen Øiseth Moen
Time: February 27 at 12:15
Place: University of Oslo, Domus Academica: Gamle festsal
Link to university website
(1) Vitamin B12 is not likely to causally affect the levels of most cardiovascular risk factors or the risk of coronary heart disease or type 2 diabetes. However, B12 could have a causal effect on fasting glucose and β cell function.
(2/3) The other two articles of the thesis focus on maternal and offspring genetic effects, as well as the genetic determinants of glucose metabolism in pregant women. Moen as developed a freely available online tool called “The Maternal and Fetal Genetic Effects Power Calculator”.
(1) Moen, G. H., Qvigstad, E., Birkeland, K. I., Evans, D. M., & Sommer, C. (2018). Are serum concentrations of vitamin B-12 causally related to cardiometabolic risk factors and disease? A Mendelian randomization study. The American journal of clinical nutrition, 108(2), 398-404.
(2) Moen, G. H., LeBlanc, M., Sommer, C., Prasad, R. B., Lekva, T., Normann, K. R., Qvigstad, E., Groop, L., Birkeland, K. I., Evans, D. M., & Frøslie, K. F. (2018). Genetic determinants of glucose levels in pregnancy: genetic risk scores analysis and GWAS in the Norwegian STORK cohort. European journal of endocrinology, 179(6), 363-372.
(3) Moen, G. H., Hemani, G., Warrington, N. M., & Evans, D. M. (2019). Calculating Power to Detect Maternal and Offspring Genetic Effects in Genetic Association Studies. Behavior genetics, 1-13.