In a cohort of 4000 patients with suspected angina pectoris, Thomas Olsen has investigated vitamin A’s impact on the cardiovascular risk associated with the traditional risk markers homocysteine and apolipoprotein A1 and B.
Circulating vitamin A can modify the association between apolipoprotein B and risk of myocardial infarction.
- Circulating vitamin A can modify the association between homocysteine and risk of myocardial infarction.
- Circulating vitamin A is positively associated with levels of creatinine, cysteine and uric acid.
Thesis: Lipids, Homocysteine and Vitamin A. Perspectives and new hypotheses from patients with cardiovascular disease
Candidate: Thomas Olsen
Time: January 16, 2020 at 13:15
Place: University of Oslo, Domus Odontologica: Store auditorium
Link to university website
(1/2) Higher concentrations of apolipoprotein B and homocysteine are linked to increased risk of myocardial infarction in patients with stable angina, but only if they also have high levels of vitamin A (retinol). Higher levels of vitamin A also modifies the association between low levels of apolipoprotein A1 and increased risk of myocardial infarction.
The studies include patients with stable angina pectoris, followed for a median of nearly five years. 8% of them had an acute myocardial infarction during follow-up. Olsen and colleagues conclude that circulating vitamin A can modify the association between apolipoproteins, homocysteine and subsequent myocardial infarction.
(3) Dietary intake does not seem to influence blood levels of vitamin A much in patients with stable angina. Olsen’s study shows a weak association between self-reported meat and vegetable intake and circulating retinol, and no association for other dietary variables.
On the other hand, creatinine – a marker of impaired renal function – is positively associated with serum levels of vitamin A. Moreover, higher levels of the amino acid cysteine and the inflammatory marker uric acid are also linked to higher vitamin A concentrations.
(1) Olsen, T., Vinknes, K. J., Svingen, G. F., Pedersen, E. R., Tell, G. S., Blomhoff, R., Drevon, C. A., Ueland, P. M., Midttun, Ø., Refsum, H., & Nygård, O. K. (2017). Cardiovascular disease risk associated with serum apolipoprotein B is modified by serum vitamin A. Atherosclerosis, 265, 325-330.
(2) Olsen, T., Vinknes, K. J., Svingen, G. F., Pedersen, E. R., Dhar, I., Tell, G. S., Blomhoff, R., Ueland, P. M., Midttun, Ø., Refsum, H., & Nygård, O. K. (2018). The risk association of plasma total homocysteine with acute myocardial infarction is modified by serum vitamin A. European journal of preventive cardiology, 25(15), 1612-1620.
(3) Olsen, T., Vinknes, K. J., Blomhoff, R., Lysne, V., Midttun, Ø., Dhar, I., Ueland, P. M., Svingen, G. F. T., Pedersen, E. K. R., Drevon, C. A., Refsum, H., & Nygård, O. K. (2019). Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease. European journal of nutrition, 1-11.