Connective Tissue Growth Factor activates protective signaling pathway in the heart

The function of Connective Tissue Growth Factor (CCN2) in ischemia-reperfusion injury and chronic pressure overload is the main theme of Tuyet Anh Pham‘s PhD thesis.


  1. Connective Tissue Growth Factor activates cytoprotective signaling in cardiomyocytes and endothelial cells.

  2. Connective Tissue Growth Factor protects cardiomyocytes and endothelial cells agains ischemia-reperfusion injury and oxidative stress.
  3. Connective Tissue Growth Factor reduces angiotensin II- and stretch-induced cardiomyocyte hypertrophy.


Thesis: A study on the cytoprotective actions of CCN2 and the role of CCN2 in angiotensin 2-induced myocardial hypertrophy
Candidate: Tuyet Anh Pham
Time: February 14, 2020 at 13:15
Place: University of Oslo, Domus Medica: Nye auditorium 13
Link to university website


(1) Connective Tissue Growth Factor (CCN2) protects against oxidative stress and cell death by activating the cytoprotective signaling pathway PI3-kinase/Akt/GSK-3β in adult cardiomyocytes and endothelial cells. Cardioprotective genes are upregulated in cardiomyocytes stimulated with CCN2. This cardioprotection is attenuated when a PI3-kinase inhibitor or Akt-inhibitor is present.

(2) Mice with overexpression of CCN2 in the heart showed attenuated hypertrophy compared to wild type mice when subjected to angiotensin II-infusion. Pro-hypertrophic NFAT-activity was reduced when CCN2 was present in neonatal cardiomyocytes exposed to mechanical stretch, indicating that CCN2 protects against hypertrophy through modulation of NFAT-activity.


(1) Moe, I. T., Pham, T. A., Hagelin, E. M. V., Ahmed, M. S., & Attramadal, H. (2013). CCN2 exerts direct cytoprotective actions in adult cardiac myocytes by activation of the PI3-kinase/Akt/GSK-3β signaling pathway. Journal of cell communication and signaling7(1), 31-47.

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