Preeclampsia adds to the mother’s risk of later cardiovascular disease. In his PhD thesis, Patji Haakon Alnæs-Katjavivi has looked at the prevalence of acute aherosis in preeclamptic women, and how it relates to cardiovascular risk.
Acute atherosis is not associated with classical cardiovascular risk factors.
Thesis: Decidual acute atherosis: immunohistochemical definition, immune cell involvement, and tissue heterogeneity
Candidate: Patji Haakon Alnæs-Katjavivi
Time: January 16, 2020 at 13:15
Place: Oslo University Hospital Ullevål, Kreftsenteret: ground floor auditorium
Link to university website
(3) Acute atherosis is generally not associated with age, BMI, lipid levels or diabetes, neither in normotensive nor preeclamptic pregnancies. However, women above 35 years oldhave higher levels of LDL cholesterol if they also have acute atherosis.
Acute atherosis is somewhat similar to early stage atherosclerosis, and implies a lesion in the arteries supplying the placenta in pregnancy. The study includes 237 women who delivered by cesarian section, of which 104 had preeclampsia
(4/2/1) More than one third of women with preeclampsia have acute atherosis, compared to around 10 % of women without preeclampsia, according to Alnæs-Katjavivi’s results. Preeclamptic women with acute atherosis give birth to children with lower weight and lower gestational age. The thesis also includes two papers that provide simplified and reproducible criteria for standardized definition and detection of acute atherosis.
(1) Alnæs-Katjavivi, P., Lyall, F., Roald, B., Redman, C., & Staff, A. (2013). Decidual acute atherosis-updating and testing diagnostic criteria.
(2) Alnaes-Katjavivi, P., Lyall, F., Roald, B., Redman, C. W., & Staff, A. C. (2016). Acute atherosis in vacuum suction biopsies of decidua basalis: an evidence based research definition. Placenta, 37, 26-33.
(3) Moe, K., Alnaes-Katjavivi, P., Størvold, G. L., Sugulle, M., Johnsen, G. M., Redman, C. W., Dechend, R., & Staff, A. C. (2018). Classical cardiovascular risk markers in pregnancy and associations to uteroplacental acute atherosis. Hypertension, 72(3), 695-702.
(4) Alnaes-Katjavivi, P., Roald, B., & Staff, A. C. (2019). Uteroplacental acute atherosis in preeclamptic pregnancies: Rates and clinical outcomes differ by tissue collection methods. Pregnancy hypertension, 19, 11.