Visceral fat is a risk factor for arterial stiffness after kidney transplantation

Marit Elizabeth von Düring‘s PhD thesis looks at associations between visceral fat, diabetes and arterial stiffness in kidney transplant recipients.


MAIN RESULTS:

  1. High prevalence of obesity among Somali immigrants in Norway.

  2. Visceral fat is strongly associated with post‐transplant diabetes mellitus.

  3. Arterial stiffness is associated with visceral fat mass in kidney transplanted patients.


THESIS DEFENCE:

Thesis: Associations between visceral fat, post transplant diabetes and arterial stiffness in kidney transplant recipients
Candidate: Marit Elizabeth von Düring
Time: December 12, 2019 at 13:15
Place: Oslo University Hospital, Rikshospitalet B: Store auditorium
Link to university website


SUMMARY:

(1/3) Glucose metabolism generally improves the first year after kidney transplantation. Visceral adipose tissue is more closely related to impaired glucose metabolism at follow-up than body mass index. The association was stronger at one year follow-up compared to after eight weeks.

150 patients were examined one year after transplantation with oral glucose tolerance tests and body composition measurements with DXA.

(2) Visceral adipose tissue is a risk factor for arterial stiffness after kidney transplantation, whereas high BMI is not. In multivariate analysis, arterial stiffness was not associated with hyperglycemia.

This analysis contains data from 162 non-diabetic kidney transplant recipients 8‐10 weeks after transplantation. Arterial stiffness was measured as pulse wave velocity.


REFERENCES:

(1) Von Düring, M. E., Jenssen, T., Bollerslev, J., Åsberg, A., Godang, K., & Hartmann, A. (2017). Visceral fat is strongly associated with post‐transplant diabetes mellitus and glucose metabolism 1 year after kidney transplantation. Clinical transplantation31(1), e12869.

(2) von Düring, M. E., Jenssen, T., Bollerslev, J., Godang, K., Hartmann, A., & Åsberg, A. (2018). Arterial stiffness is associated with visceral fat mass in kidney transplanted patients—A nationwide cohort study. Clinical transplantation32(8), e13341.